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Patients who remained on tacrine and were receiving doses>80 mg/d or>120 mg/d were less likely to have entered a nursing home than patients on lower doses(odd ratios>2.7,2.8,respectively.)There was a trend for lower mortality for patients receiving>120 mg/d(p=0.063).Conclusions:Treatment with tacrine at doses>80 mg/d was associated with a reduced likelihood of NHP.These data demonstrate that tacrine's 30-week effects on cognitive function and clinicians'global ratings may generalize to effects on a major milestone of AD.Future studies should attempt to replicate these findings prospectively. |
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